Pengaruh Pemberian Ekstrak Daun Mahkota Dewa pada Gambaran Histopatologi Paru Tikus Putih yang Dipapar Asap Rokok



Background: Smoking is a bad habit for health. There are many dangerous components inside a cigarette. The smoke that comes out from the cigarette contains many harmful components. Smoking and getting exposed to cigarette smoke in a long period of time can cause inflammatory response on respiratory tract. Mahkota dewa leaf contains beneficial biological component, such as flavonoidalkaloid, andsaponin that have anti-inflammatory, anti-cancer, and many others.

Aim :The purpose of this research was to determine the effect of administration of mahkota dewa leaf (Phaleria macrocarpa) extract onlung histopathology in white male Wistar rats (Rattus norvegicus) exposed to cigarette smoke.

Methods : This research is a true laboratory experimental research using Post-Test Only Control Group Design. The subject in this research were 30 male Wistar Rats (Rattus norvegicus) which were divided into 4 groups, a group without given any treatment (K-), a group where they only getting exposed to cigarette smoke (K+), a group where they exposed to cigarette smoke and given mahkota dewa leaf extract at 1500 mg/kgBW/day dose (Eg1), and the group exposed to cigarette smoke and a mahkota dewa leaf extract at a 2500 mg/kgBW/day dose (Eg2).

Result            : 1.) There was a significant difference on lung histopathology between K- and K+, Eg1, and Eg2. 2.) There was no significant difference on lung histopathology between K+, Eg1 and Eg2.

Conclusion : Exposure to 5 cigarette smoke in 21 days caused lung histopathology changes. However, there was no effect of the administration of mahkota dewa leaves extract at 1500 mg/kgBW/day and 2500 mg/kgBW/day on lung histopathology of white male Wistar rats exposed to 5 cigarette smoke in 21 days.

Keyword : Phaleria macrocarpa leaf, Flavonoid, Alkaloid, cigarette smoke, inflammatory response, Infiltration of Inflammatory cells.

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Hang Tuah Medical Journal (Print ISSN: 1693-1238 | Online ISSN: 2598-4861) is licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. Published by Hang Tuah University Press, Surabaya, Indonesia.