Downregulates of ICAM1 expression in Myometrium from pregnant Rattus novergicus infected with Tachyzoite of Toxoplasma gondii with Hyperbaric Oxygen Therapy




Background: To find the effect of Hyperbaric Oxygen Therapy in the myometrium expressions of ICAM1 from pregnant Rattus norvegicus infected with Tachyzoite Toxoplasma gondii.

Material and Methods :

This is an experimental study with a post-test only design on 37 pregnant Rattus norvegicus Sprague Dawley, then the rats were divided into 4 groups. The HBOT group A is pregnant rats infected with tachyzoite received therapy 10 sessions of HBOT 2.4 ATA in 3x30 minutes; the group B is Pregnant only and get no HBOT; the group C is Pregnant and infected with tachyzoite T.gondii but not received HBOT, and the group D is normal pregnant rats. Each infected pregnant rats were given a 103 Tachyzoite of Toxoplasma gondii via intraperitoneal. Examinations of ICAM1 expressions were performed on day-5 after HBOT (twice a day). Rats were killed and the myometrial ICAM1 levels were measured with Immunohistochemistry examination. All data were analyzed with the ANOVA test with SPSS 21 Program.

Results: The results show that Hyperbaric Oxygen Therapy can downregulate ICAM1 in the administered of HBO 2.4 ATA for 3x30 minutes in 10 sessions over 5 days of therapy.

Conclusion: The study concludes that HBOT can downregulate the expressions of ICAM1 in the myometrium, in the provision of HBO 2.4 ATA for 3x30 minutes in 10 sessions.


HBOT, ICAM1, Tachyzoite Toxoplasma gondii

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Hang Tuah Medical Journal (Print ISSN: 1693-1238 | Online ISSN: 2598-4861) is licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. Published by Hang Tuah University Press, Surabaya, Indonesia.