Faktor-Faktor yang Berhubungan Dengan Kejadian Proteinuria pada Pasien Diabetes Melitus di Puskesmas I dan IV Denpasar Selatan
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Abstract
Diabetes Mellitus (DM) is a major health problem in the world. Various complications can arise due to uncontrolled blood sugar levels. One of the complications of DM involving the kidneys is diabetic nephropathy, which is characterized by the occurrence of proteinuria in DM patients. This study aims to determine the factors associated with the incidence of proteinuria in patients with diabetes mellitus at Puskesmas I and IV Denpasar Selatan. The design in this study is an analytical study with a cross sectional approach using primary data obtained from interviews and urinalysis examinations. The minimum sample size in this study was 106 people who met the inclusion and exclusion criteria. Data were analyzed using Chi Square test with a significance level of 5%. The number of respondents in this study were 106 respondents. The results of this study showed that as many as 33% of all DM patients had proteinuria. There is a significant relationship between the onset of DM and the incidence of proteinuria (p<0.05), so it can be interpreted that the longer the duration of experiencing DM, the incidence of proteinuria will increase, and vice versa. There was no significant relationship between age, gender, BMI, type of DM therapy, and fasting blood glucose levels with the incidence of proteinuria (p>0,05). Patients with diabetes onset more than 10 years tend to have proteinuria. DM patients are advised to do regular proteinuria checks if the onset of DM is more than 5 years.
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References
Abdelhafiz, A. H. 2020. Diabetic Kidney Disease in Older People with Type 2 Diabetes Mellitus: Improving Prevention and Treatment Options, Drugs and Aging. Springer International Publishing, 37(8), pp. 567–584. doi: 10.1007/s40266-020-00773-y.
Akhsyari, F. Z. 2016. Karakteristik Pasien Diabetes Mellitus di RSUD d. Soehadi Prijonegoro Sragen tahun 2015, p. 6.
Al-Shammakh, A. A., Ali, A. D. and Jermozy, H. Al. 2019. Prevalence of Proteinuria among Type 2 Diabetic Patients in Dhamar Governorate, Yemen, International Journal of Diabetes and Clinical Research, 6(2), pp. 1–7. doi: 10.23937/2377-3634/1410106.
Alza, Y., Arsil, Y., Marlina, Y., Novita, L., Agustin, N. D. 2020. Aktivitas Fisik, Durasi Penyakit Dan Kadar Gula Darah Pada Penderita Diabetes Mellitus (Dm) Tipe 2, Jurnal GIZIDO, 12(1), pp. 18–26. doi: 10.47718/gizi.v12i1.907.
Antari, N. K. N. 2017. Diabetes Melitus Tipe 2, Fakultas Kedokteran, Universitas Lampung. Available at: https://simdos.unud.ac.id/uploads/file_penelitian_1_dir/653f627b3ce1272d209353541c305cee.pdf.
Ariceta, G. 2011. Clinical practice: Proteinuria, European Journal of Pediatrics, 170(1), pp. 15–20. doi: 10.1007/s00431-010-1334-0.
Azitha, M., Aprilia, D. and Ilhami, Yose, R.I. 2018. Hubungan Aktivitas Fisik dengan Kadar Glukosa Darah Puasa pada Pasien Diabetes Melitus yang Datang ke Poli Klinik Penyakit Dalam Rumah Sakit M. Djamil Padang, Jurnal Kesehatan Andalas, 7(3), p. 400. doi: 10.25077/jka.v7i3.893.
Bellary, S., Kyrou, I., Brown, J. E., Bailey, C. J. 2021. Type 2 diabetes mellitus in older adults: clinical considerations and management, Nature Reviews Endocrinology. Springer US, 17(9), pp. 534–548. doi: 10.1038/s41574-021-00512-2.
Chawla, A., Chawla, R. and Jaggi, S. 2016. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?, Indian Journal of Endocrinology and Metabolism, 20(4), pp. 546–553. doi: 10.4103/2230-8210.183480.
Cobo, G., Hecking, M., Port, F. Exner, I., Lindholm, B., Stenvinkel, P. 2016. Sex and gender differences in chronic kidney disease: Progression to end-stage renal disease and haemodialysis, Clinical Science, 130(14), pp. 1147–1163. doi: 10.1042/CS20160047.
Dimple, Arora, V., Arora, M., Kaur, P., Arora, A. 2016. Prevalence And Determinants Of Proteinuria In Type 2 Diabetes Original Article Prevalence And Determinants Of Proteinuria In Type 2 Diabetes Mellitus, (February).
Dinas Kesehatan Kota Denpasar. 2019. Laporan Tahunan Dinas Kesehatan Kota Denpasar 2018, pp. 1–221. Available at: https://dinkes.denpasarkota.go.id/uploads/download/download_192207090740_LaporanTahunanDinasKesehatanKotaDenpasar2018.pdf.
Ephraim, R. K. D., Eghan, B. A. and Quaye, L. 2013. Prevalence and Determinants of Proteinuria Among Type 2 Diabetics in Kumasi, Ghana, Journal of Medical and Biomedical Sciences, 2(1).
Fahmiyah, I. and Latra, I. 2016. Faktor yang Memengaruhi Kadar Gula Darah Puasa Pasien Diabetes Mellitus Tipe 2 di Poli Diabetes RSUD Dr. Soetomo Surabaya Menggunakan Regresi Probit Biner, Jurnal Sains dan Seni ITS, 5(2), pp. 456–461.
Fineberg, D., Jandeleit-Dahm, K. A. M. and Cooper, M. E. 2013. Diabetic nephropathy: Diagnosis and treatment, Nature Reviews Endocrinology. Nature Publishing Group, 9(12), pp. 713–723. doi: 10.1038/nrendo.2013.184.
Hidayati, P. H., Abdullah, R. P. I. and Budiman. 2019. Hubungan Antara Gula Darah Puasa dan Proteinuria Pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Ibnu Sina Makassar Prema, Wal’afiat Hospital Journal, pp. 1–8.
Kasa, A. 2019. Karakteristik Pasien Diabetes Mellitus Tipe 2 Di Instalasi Rawat Inap Rumah Sakit Pendidikan Universitas Hasanuddin Kota Makassar Periode Januari 2018 – September 2019.
Kemenkes RI. 2020. Diabetes Mellitus, Pusat Data dan Informasi Kementrian Kesehatan RI.
Komariah, K. and Rahayu, S. 2020. Hubungan Usia, Jenis Kelamin Dan Indeks Massa Tubuh Dengan Kadar Gula Darah Puasa Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Pratama Rawat Jalan Proklamasi, Depok, Jawa Barat, Jurnal Kesehatan Kusuma Husada, (Dm), pp. 41–50. doi: 10.34035/jk.v11i1.412.
Lachin, J. M., Viberti, G., Zinman, B., Haffner, S., Aftring, P., Paul, G, et al. 2011. Renal function in type 2 diabetes with rosiglitazone,metformin, and glyburide monotherapy, Clinical Journal of the American Society of Nephrology, 6(5), pp. 1032–1040. doi: 10.2215/CJN.09291010.
Lestari, I., Rizka, D., Hidayati, P. H., Basri, P. L., Hidayah, N. 2019. Proteinuria Pasien Diabetes Melitus dan Obesitas Poli Penyakit Dalam RS Ibnu Sina Makassar, Green Medical Journal : Jurnal Kedokteran, 1(1), pp. 1–8.
Liang, H., Ma, S., Xiao, Y., Tan, H. 2017. Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus, Medicine, 96(38), p. e7939. doi: 10.1097/md.0000000000007939.
Mardewi, I. and Suastika, K. 2016. Hubungan Status Nutrisi Dengan Derajat Proteinuria Pada Pasien Diabetes Melitus Tipe 2 Dengan Komplikasi Nefropati Diabetik Di Rsup Sanglah, E-Jurnal Medika Udayana, 5(6), pp. 1–6.
Milita, F., Handayani, S. and Setiaji, B. 2021. Kejadian diabetes mellitus tipe II pada lanjut usia di Indonesia (analisis riskesdas 2018 ), Jurnal Kedokteran dan Kesehatan, 17(1), pp. 9–20.
Mirzaei, Rahmaninan, M., Nadjarzadeh, A., Tafti, A. 2020. Epidemiology of diabetes mellitus, pre-diabetes, undiagnosed and uncontrolled diabetes in Central Iran: Results from Yazd health study, BMC Public Health. BMC Public Health, 20(1), pp. 1–9. doi: 10.1186/s12889-020-8267-y.
Pratama, A., Chasani, S. and Santoso, S. 2013. Korelasi Lama Diabetes Melitus Terhadap Kejadian Nefropati Diabetik : Studi Kasus Di Rumah Sakit Dokter Kariadi Semarang, Jurnal Kedokteran Diponegoro, 2(1), p. 109938.
Pratiwi, S. 2016. Gambaran Proteinuria pada Penderita Diabetes Melitus di RSUP Dr. Mohhamad Hoesin Kota Palembang Tahun 2016, Karya Tulis Ilmiah, 9(August), p. 10. Available at: https://www.infodesign.org.br/infodesign/article/view/355%0Ahttp://www.abergo.org.br/revista/index.php/ae/article/view/731%0Ahttp://www.abergo.org.br/revista/index.php/ae/article/view/269%0Ahttp://www.abergo.org.br/revista/index.php/ae/article/view/106.
Selim, S. et al. (2021) ‘Demographic, Clinical and Biochemical Characteristics of Drug Naive Type 2 Diabetes Patients of Bangladesh’, Open Journal of Endocrine and Metabolic Diseases, 11(08), pp. 145–154. doi: 10.4236/ojemd.2021.118012.
Sihotang, R. C., Ramadhani, R. and Tahapary, D. L. (2018) ‘Efikasi dan Keamanan Obat Anti Diabetik Oral pada Pasien Diabetes Melitus Tipe 2 dengan Penyakit Ginjal Kronik, Jurnal Penyakit Dalam Indonesia, 5(3), p. 150. doi: 10.7454/jpdi.v5i3.202.
Singh, S., Nabi, M., Saiffuddin, M., Hannan, M., Bakar, M. A., Talukder, S., et al. 2020. Sex difference in the incidence of microvascular complications in patients with type 2 diabetes mellitus: a prospective cohort study, Acta Diabetologica. Springer Milan, 57(6), pp. 725–732. doi: 10.1007/s00592-020-01489-6.
WHO. 2021. Diabetes, (April), pp. 1–7. Available at: https://www.who.int/es/news-room/fact-sheets/detail/diabetes.