Pengaruh Obesitas pada Status Imunitas Individu Terhadap Infeksi Virus Dan Bakteri
DOI:
https://doi.org/10.30649/htmj.v19i1.12Keywords:
obesitas, system imunitas, infeksi bakteri dan virusAbstract
Obesity is a chronic disorder which the incidence rate increases rapidly, especially in the Covid-19 pandemic due to limited daily physical activity and efforts to increase daily intake even though the initial goal is to increase immunity. Whatever the reason, obesity, is the part of malnutrition that must be watched out because it actually has big impact on health problems that can be fatal. What is highlighted here is the disruption of the immune system against bacterial or viral infections. With the advancement of medical science in the field of biomolecules, many parameters of the immune system have been shown to decrease both in quality and quantity in obesity conditions that cause susceptibility to infection.
Keywords : obesity, immunity system, bacterial and viral infection
References
Abdelaal M, le Roux CW, Docherty NG, 2017. Morbidity and mortality associated with obesity. Ann Transl Med. Apr; 5(7): 161
Andersen CJ, Murphy KE, Fernandez ML, 2016. Impact of Obesity and Metabolic Syndrome on Immunity, Adv Nutr:7:66–75
Ahima RS., Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000;11:327-332
Dobner J, Kaser S, 2018. Body mass index and the risk of infection - from underweight to obesity, Clin microbiol and infect 24: 24-28
Dossett LA, Dageforde LA, Swenson BR, Metzger R, Bonatti H, Sawyer RG, May AK, 2009. Obesity and Site-Specific Nosocomial Infection Risk in the Intensive Care Unit, Surg Infect, Vol 10, 2: 137-42
Fantuzzi G, 2005. Adipose tissue, adipokines and inflammation. J Allergy Clin Immunol; 115:911-19
Folds JD, Schmitz JL, 2003. Clinical and laboratory assessment of immunity. J Allergy Clin Immunol, Vol 111, 2: 702-11
Francisco V, Pino J, Campos-Cabaleiro V, Ruiz-Fernández C, Mera A, Gonzalez-Gay MA, Gómez R and Gualillo O, 2018. Obesity, Fat Mass and Immune System: Role for Leptin, Frontiers in Physiology , vol 9, article 640
Fruhbeck G., Gomez-Ambrosi J., Muruzabal FJ., Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. 2001 Jun;280(6):E827-47
Haslam DW, James WP. Obesity. Lancet 2005;366:1197-209
Hussain A, Mahawar K, Xia Z, Yang W, El-Hasani S, 2020. Obesity and mortality of COVID-19. Meta-analysis. Obes Res Clin Pract. July-August; 14(4): 295–300
Ghanim H, Aliada A, Hofmeyer D, et al, 2004. Circulating mononuclear cells in the obese are in proinflammatory state, Circulation, 110:1564-71
Guilherme A, Virbasius JV, Puri V, Czech MP, 2008. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes, Nat Rev Mol Cell Biol. May; 9(5):367-77
Grier WR, Kratimenos P, Singh S, Guaghan JP, Koutroulis I. Obesity as a riskfactor for urinary tract infection in children. Clin Pediatr (Phila) [Internet].SAGE Publications 2016 Jan 24;55:952e6
Iwasaki H, Akashi K, 2007. Myeloid lineage commitment from the hematopoieticstem cell. Immunity, 26:726–40.
Kementrian Kesehatan Republik Indonesia. Hasil Utama Riskesdas 2018. http://www.depkes.go.id/resources/download/info-terkini/hasil-riskesdas-2018.pdf.
Kim K, Kim JK, Han SH, et al, 2006. Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol; 176: 5958-64
Koerner A, 2005. Adipocytokines: leptin, the classical resistin the controversial adiponectin, the promising and more to come. Best Pract res Clin Endocrinol Metab;10:525-46
La cava A, Matarese G, 2004. The weight of leptin in immunity. Rev Immunol; 4: 371-9
Kullo IJ, Hensrud DD, Allison TG: Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, > or =30). Am J Cardiol 89:1441–1443, 2002
Lagathu C, Yvan-Charvet L, Bastard JP, Maachi M, Quignard-Boulange A, Capeau J, Caron M, 2006. Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia ;49:2162–73
Milner JJ, Beck MA, 2012. The impact of obesity on the immune response to infectionProceedings of the Nutrition Society (2012), 71, 298–306
Riskesdas, 2013. Prevalensi obesitas hal 223-225
Serhan CN, Chiang N, Van Dyke TE, 2008. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol, 8:349–61.
Takahama Y, 2006. Journey through the thymus: stromal guides for T-celldevelopment and selection. Nat Rev Immunol;6:127–35.
Tamara A, Tahapary DL, 2020. Obesity as a predictor for a poor prognosis of COVID-19: A systematic Review, Diabetes & Metabolic Syndrome: Clin Res & Rev 14 (2020) 655-59
Tilg H, Moschen AR, 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat rev Immunol;6:772-83
Wijga AH, Scholtens S, Bemelmans WJE, de Jongste JC, Kerkhof M, Schipper M,et al. Comorbidities of obesity in school children: a cross-sectional study inthe PIAMA birth cohort. BMC Public Health [Internet] 2010;10:184
Wensveen FM, Valentic S, Sestan M, Wensveen TT, Polic B, 2015. Interactions between adipose tissue and the immune system in health and malnutrition. Nut and Immunol, Vol 27, Issue 5: 322-33
Whitlock G, Lewington S, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009;373:1083-96
Wolf AM, Wolf D, Rumpold H, et al, 2004. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1 RA in human leukocytes. Biochem Biophys Res Commun; 323:630-35
World Health Organization, [accessed 20 August 2011] Obesity and Overweight. 2011. http://www.who.int/mediacentre/factsheets/fs311/en/index.html
Yang H, Youm YH, Vandanmagsar B, et al., 2009. Obesity accelerates thymic aging. Blood; 114:3803-12
Ziegler-Heitbrock H, Wedel A, Schraut W, et al., 1994. Tolerance to lipopolisaccaride involves mobilization of nuclear factor Kappa B with predominance of p50 homodimers. J Biol Chem; 269:17001-4






