Pengaruh Pemberian Ekstrak Biji Petai (Parkia speciosa) Terhadap Gambaran Histopatologi Ginjal Bagian Tubulus Proksimal Pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang diinduksi Paracetamol

Abstract

Abstract

Background.Paracetamol, which is one of the NSAIDs (Non Steroidal Anti Inflammatory Drugs) is widely used by the wider community as a therapeutic and pain-reducing therapy. In addition to its many uses, paracetamol can cause a variety of serious toxicities, including nephrotoxicity. Bitter bean extract (Parkia speciosa) has a flavonoid compound which is an antioxidant. Methods.This was a laboratory experimental study with post-test only controlgroup design using 24 rats divided into 3 groups. Positive control group fed with standard diet, aquades and bitter bean extract (Parkia speciosa); each rat in the treatment group 1 was induced with paracetamol 9 mg / day orally; and each rat in the treatment group 2 was given bitter bean extract (Parkia speciosa) 7,2 mg / day induced paracetamol 9 mg / day after 45 min. The kidneys were taken by surgery on the 15th day and microscopically examined. The data were analyzed using IBM SPSS version 23 with Kruskal-Wallis method. Result. Data analysis using Mann Whitney test showed significant difference between positive control group and treatment 1 p = 0.000 (p <0,05). Also in comparison between the positive control group and the treatment group 2 showed a significant difference p = 0.001 (p <0.05). However, there was no significant difference between treatment group 1 and treatment group 2 p = 0,678 (p> 0,05). Conclusion. The administration of grain seed extract (Parkia speciosa) did not decrease paracetamol-induced kidney damage