Penatalaksanaan Pasien Penyakit Jantung Koroner Di RSPAL dr. Ramelan Surabaya

NADIFA FAULIZA ZULVINA; M. FATHUDDIN AL-ISLAMI; NABELLA CHOLIDATUN NIKMAH; NADHIFA NURIZZAH DHIYANISA; NADIFA SALMA SARI; ROOSTANTIA INDRAWATI; INTAN KOMALASARI

doi:10.30649/htmj.v22i2.503

Authors

NADIFA FAULIZA ZULVINA Faculty of Medicine, Hang Tuah University, Surabaya
M. FATHUDDIN AL-ISLAMI Faculty of Medicine, Hang Tuah University, Surabaya
NABELLA CHOLIDATUN NIKMAH Faculty of Medicine, Hang Tuah University, Surabaya
NADHIFA NURIZZAH DHIYANISA Faculty of Medicine, Hang Tuah University, Surabaya
NADIFA SALMA SARI Faculty of Medicine, Hang Tuah University, Surabaya
ROOSTANTIA INDRAWATI Faculty of Medicine, Hang Tuah University, Surabaya
INTAN KOMALASARI Faculty of Medicine, Hang Tuah University, Surabaya

DOI:

https://doi.org/10.30649/htmj.v22i2.503

Keywords:

Coronary Heart Disease, Evaluation of Drug Use, Drug Evaluation, Outpatient

Abstract

Background: World Health Organization (WHO) data shows that coronary heart disease is the highest mortality and morbidity throughout the world among other heart and vascular diseases, namely around 43%. The pharmacological therapy is evaluated based on the rationality of drug use including the right indication, the right drug, the right patient and the right dose. The aim of evaluating rational drug use is to ensure that patients receive treatment that suits their needs and at an affordable price. The rational use of drugs is important in the success of disease and improving the quality of health.

Methode: The method in research uses an observational analytical method with a retrospective cross-sectional approach, with a purposive sampling technique. Data obtained from the patient's medical record status. The population in this study were all outpatients with a diagnosis of coronary heart disease in The Polyclinic Cardiology Department at RSPAL dr. Ramelan Surabaya period of January – March 2023. Result : The most patient characteristics based on range of age were in the 56 until 65 years old, namely 113 patients (33.43%). Characteristics of patients based on gender, the highest number of coronary heart medication users were men, 240 patients (71%). Characteristics of patients based on comorbidities (with comorbidities) were mostly with comorbidities, 296 patients (88%). The percentage of rational drugs of use includes the right indication (78.70%), the right drug (82.25%), the right dose (100%), and the right patient (99.11%).

Conclusion: The rationale for using coronary heart medication in coronary heart patients in the outpatient installation at RSPAL dr. Ramelan Surabaya is 94.30% rational.

Keywords: Coronary Heart Disease, Evaluation of Drug Use, Drug Evaluation, Outpatient.

References

AHA (2015) ‘Coronary Artery Disease - Coronary Heart Disease | American Heart Association’, American Heart Association.

American Diabetes Association (2016) ‘Diabetes Guidelines Summary Recommendation from NDEI’, National Diabetes Education Initiative, 39(1).

Benjamin, E.J. et al. (2018) ‘Heart disease and stroke statistics - 2018 update: A report from the American Heart Association’, Circulation, 137(12). doi:10.1161/CIR.0000000000000558.

Braun, M.M., Stevens, W.A. and Barstow, C.H. (2018) ‘Stable Coronary Artery Disease: Treatment’, American family physician, 97(6), pp. 376–384.

Chusna, S. (2015) ‘Pola Penggunaan Obat Pada Pasien Penyakit Jantung Koroner Rawat Inap Di Rumah Sakit “A” Kudus Tahun 2012’, Teaching and Teacher Education, 12(1).

Daniati and Erawati (2018) ‘HUBUNGAN TEKANAN DARAH DENGAN KADAR KOLESTEROL LDL ( Low’, Jurnal Kesehatan Perintis, 5(2).

Devon, H.A., Mirzaei, S. and Zègre-Hemsey, J. (2020) ‘Typical and atypical symptoms of acute coronary syndrome: Time to retire the terms?’, Journal of the American Heart Association, 9(7). doi:10.1161/JAHA.119.015539.

Feldman, R.D. (2020) ‘Heart disease in women: Unappreciated challenges, GPER as a new target’, International Journal of Molecular Sciences. doi:10.3390/ijms17050760.

Ford, T.J., Corcoran, D. and Berry, C. (2018) ‘Stable coronary syndromes: Pathophysiology, diagnostic advances and therapeutic need’, Heart. doi:10.1136/heartjnl-2017-311446.

Fudholi, A. et al. (2022) ‘Evaluasi Penggunaan Obat Berdasarkan Indikator Kinerja Pelayanan Kefarmasian Pada Puskesmas Wilayah Kota Kupang’, Majalah Farmaseutik, 18(2). doi:10.22146/farmaseutik.v1i1.54770.

Hakim, A.R. and Muhani, N. (2020) ‘HUBUNGAN DISLIPIDEMIA, HIPERTENSI, RIWAYAT DIABETES MELITUS TERHADAP KEJADIAN SINDROMA KORONER AKUT PADA PASIEN POLI JANTUNG DI RSUD AHMAD YANI METRO LAMPUNG 2019’, Jurnal Ilmu Kedokteran dan Kesehatan, 7(2). doi:10.33024/jikk.v7i2.2737.

Hoda, S.A. and Cheng, E. (2017) ‘Robbins Basic Pathology’, American Journal of Clinical Pathology, 148(6). doi:10.1093/ajcp/aqx095.

Hur, K.Y. et al. (2020) ‘Metformin treatment for patients with diabetes and chronic kidney disease: A korean diabetes association and korean society of nephrology consensus statement’, Kidney Research and Clinical Practice, 39(1), pp. 32–39. doi:10.23876/j.krcp.20.012.

Juli, P., Kundiman, E.M.S. and Tjitrosantoso, H. (2015) ‘Evaluasi Kerasionalan Penggunaan Antibiotik Pada Pasien Lansia Dengan Bronkitis Kronik Eksaserbasi Akut Yang Dirawat Jalan Di Rsup Prof. Dr. R. D. Kandou Manado Periode Juli 2013-Juni 2014’, Pharmacon, 4(3).

Karundeng, J.T., Prabowo, W.C. and Ramadhan, A.M. (2018) ‘Pola Pengobatan pada Pasien Congestive Heart Failure (CHF) Di Instalasi Rawat Inap RSUD Abdul Wahab Sjahranie Kota Samarinda’, Proceeding of Mulawarman Pharmaceuticals Conferences, 8. doi:10.25026/mpc.v8i1.328.

KDIGO (2022) ‘KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease’, Kidney international, 102(5). doi:10.1016/j.kint.2022.06.008.

Kemenkes RI (2019) KEPUTUSAN MENTERI KESEHATAN REPUBLIK INDONESIA NOMOR HK.01.07/MENKES/675/2019 TENTANG PEDOMAN NASIONAL PELAYANAN KEDOKTERAN TATA LAKSANA SINDROMA KORONER AKUT, Kementerian Kesehatan Republik Indonesia. DKI Jakarta.

Kementerian Kesehatan RI (2011) Modul Penggunaan Obat Rasional. Jakarta: Bina Pelayanan Kefarmasian.

Kementerian Kesehatan RI (2018) ‘Riskesdas 2018’, Laporan Nasional Riskesdas 2018, 44(8).

Khairurrijal, M.A.W. and Putriana, N.A. (2018) ‘Review : Medication Erorr Pada Tahap Prescribing, Transcribing, Dispensing, dan Administration’, Farmasetika.com (Online), 2(4). doi:10.24198/farmasetika.v2i4.15020.

Lestari, R.D., Dewi, R. and Sanuddin, M. (2020) ‘Evaluasi Penggunaan Obat Pada Pasien Penyakit Jantung Koroner di Instalasi Rawat Inap RSUD Raden Mattaher Jambi’, Journal of Healthcare Technology and Medicine, 6(1).

Ma’rufi, R. and Rosita, L. (2014) ‘HUBUNGAN DISLIPIDEMIA DAN KEJADIAN PENYAKIT JANTUNG KORONER’, Jurnal kedokteran dan kesehatan Indonesia, 6(1). doi:10.20885/jkki.vol6.iss1.art7.

Mahmuda, I.N.N. et al. (2021) ‘Coronary Heart Disease: Diagnosis and Therapy’, Solo Journal of Anesthesi, Pain and Critical Care (SOJA), 1(2), p. 74. doi:10.20961/soja.v1i2.55191.

Monica, R.F., Laksono Adiputro, D. and Marisa, D. (2019) ‘HUBUNGAN HIPERTENSI DENGAN PENYAKIT JANTUNG KORONER PADA PASIEN GAGAL JANTUNG DI RSUD ULIN BANJARMASIN’, Hemeostasis [Preprint].

Mpila, D.A. and Lolo, W.A. (2022) ‘Hubungan Rasionalitas Penggunaan Obat Antihipertensi Terhadap Outcome Klinis Pasien Hipertensi Di Klinik Imanuel Manado’, Pharmacon, 11(1), pp. 1350–1358.

NIH (2018) Coronary Heart Disease | National Heart, Lung, and Blood Institute (NHLBI), National Heart,Lung, and Blood Institute.

Ostrowska, M. and Kubica, J. (2018) ‘Carvedilol – is it still the primus inter pares among b-blockers?’, Medical Research Journal, 3(3), pp. 165–174. doi:10.5603/mrj.2018.0028.

P2PTM (2018) Klasifikasi Hipertensi, Kemenkes RI.

PERKI (2015) Pedoman Tatalaksana Sindrom Koroner Akut Edisi Ketiga. Edisi Keti. Jakarta.

PERKI (2019) Panduan Evaluasi Dan Tatalaksana Angina Pektoris Stabil. Pertama. Edited by A.A. Alkatiri et al. Perhimpunan Dokter Spesialis Kardiovaskuler Indonesia.

Perkumpulan Endokrinologi Indonesia (2019) Pedoman Pengelolaan Dislipidemia di Indonesia 2019, PB PERKENI.

Rahmawati, I., Dwiana, D. and Ratiyun, R.S. (2020) ‘Hubungan Diabetes Melitus (DM) dengan Penyakit Jantung Koroner (PJK) pada Pasien yang Berobat di Poli Jantung’, Jurnal Kesehatan Dr. Soebandi, 8(1).

Regmi, M. and Siccardi, M.A. (2023) ‘Coronary Artery Disease Prevention’, Manual of Heart Failure Management [Preprint].

Safri, Z. (2018) ‘Management of coronary artery disease’, in IOP Conference Series: Earth and Environmental Science. doi:10.1088/1755-1315/125/1/012125.

Sihotang, R.C., Ramadhani, R. and Tahapary, D.L. (2018) ‘Efikasi dan Keamanan Obat Anti Diabetik Oral pada Pasien Diabetes Melitus Tipe 2 dengan Penyakit Ginjal Kronik’, Jurnal Penyakit Dalam Indonesia, 5(3). doi:10.7454/jpdi.v5i3.202.

Stouffer, G.A. et al. (2019) Netter’s Cardiology Third Edition, Netter’s Cardiology. Elseiver.

Sukandar, E.Y., Andrajati, R., Sigit, J.I., Adayana, I.K., Setiadi, A.P. and Kusnandar (2013) ISO Farmakoterapi Buku 1. Jakarta: ISFI Penerbitan.

Syukri, A.E.D.P. (2013) ‘PROFIL PENYAKIT JANTUNG KORONER DI IRINA F JANTUNG RSUP PROF. Dr. R. D. KANDOU MANADO’, e-CliniC, 1(1). doi:10.35790/ecl.1.1.2013.6036.

T. Bahri Anwar (2019) ‘Faktor Risiko Penyakit Jantung Koroner (PJK)’, pp. 1–15.

Taroreh, G., Mpila, D. and Citraningtyas, G. (2017) ‘Evaluasi Penggunaan Obat Pada Pasien Dengan Penyakit Jantung Koroner Di Instalasi Rawat Inap Rsup Prof. Dr. R. D. Kandou Manado’, Pharmacon, 6(4). doi:10.35799/pha.6.2017.17718.

Themistocleous, I., Stefanakis, M. and Douda, H.T. (2017) ‘Coronary Heart Disease Part I : Pathophysiology and Risk Factors’, Journal of Physical Activity, Nutrition and Rehabilitation [Preprint].

Tsao, C.W. et al. (2022) ‘Heart Disease and Stroke Statistics-2022 Update: A Report from the American Heart Association’, Circulation. doi:10.1161/CIR.0000000000001052.

Untari, E.K. et al. (2018) ‘Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Puskesmas Siantan Hilir Kota Pontianak Tahun 2015’, Pharmaceutical Sciences and Research, 5(1), pp. 32–39. doi:10.7454/psr.v5i1.3870.

Wang, H. et al. (2022) ‘Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants’, Genes and Diseases. doi:10.1016/j.gendis.2020.11.003.

Whitlock, R.H. et al. (2020) ‘A Safety Comparison of Metformin vs Sulfonylurea Initiation in Patients With Type 2 Diabetes and Chronic Kidney Disease: A Retrospective Cohort Study’, Mayo Clinic Proceedings, 95(1). doi:10.1016/j.mayocp.2019.07.017.

Widmayer, E. p., Raff, H. and Strang, K.T. (2019) Vander’s Human Physiology, Igarss.

Wulandari, T., Nurmainah and Robiyanto (2015) ‘Gambaran Penggunaan Obat Pada Pasien Gagal Jantung Kongestif Rawat Inap Di Rumah Sakit Sultan Syarif Mohamad Alkadrie Pontianak’, jurnal Farmasi Kalbar, 3(1).

Yudi H. Oktaviono, Djoko Soemantri; Mohammad Yogiarto, Budi Susetyo Pikir, Rochmad Romdoni, R.P. Soeharsohadi, Muhammad Aminuddin, Iswanto Pratanu, Esti Hindariati, Agus Subagjo, Budi B.Dharmadjati, Rurus Suryawan, Achmad Lefi, D. (2020) Buku Ajar Ilmu Penyakit Jantung dan Pembuluh Darah. 1st edn. Surabaya: Airlangga University Press.

Zahrawardani, D., Herlambang, K.S. and Anggraheny, H.D. (2013) ‘Analisis Faktor Risiko Kejadian Penyakit Jantung Koroner di RSUP Dr Kariadi Semarang’, Jurnal Kedokteran Muhammadiyah, 1(3).

Zhang, Y. et al. (2020) ‘Real-world use of ACEI/ARB in diabetic hypertensive patients before the initial diagnosis of obstructive coronary artery disease: Patient characteristics and long-term follow-up outcome’, Journal of Translational Medicine, 18(1). doi:10.1186/s12967-020-02314-y.