Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak

SRILA NATASWARI ANAK AGUNG ISTRI AGUNG; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU

doi:10.30649/htmj.v22i2.576

Authors

SRILA NATASWARI ANAK AGUNG ISTRI AGUNG Faculty of Medicine, Hang Tuah University, Surabaya
LESTARI DEWI Faculty of Medicine, Hang Tuah University, Surabaya
SOEDARSONO Faculty of Medicine, Hang Tuah University, Surabaya
INDRI NGESTI RAHAYU Faculty of Medicine, Hang Tuah University, Surabaya

DOI:

https://doi.org/10.30649/htmj.v22i2.576

Keywords:

Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet

Abstract

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet.

This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups.

The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels.

Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet

References

Berberich, A.J. and Hegele, R.A., 2022. A Modern Approach to Dyslipidemia. Endocrine Reviews, 43(4), pp.611–653. https://doi.org/10.1210/endrev/bnab037.

Djoni Husodo, S., Rietta Kumala, A., Ngesti Rahayu, I., Fisiologi Fakultas Kedokteran Universitas Hang Tuah, B., Gadung No, J., Barat RSPAL Ramelan Surabaya, K. and Timur, J., 2021. HANG TUAH MEDICAL JOURNAL Ekstrak Kulit Pisang Kepok (Musa paradisiaca) Menurunkan Kadar AST pada Tikus Putih yang Diinduksi Diet Tinggi Lemak. [online] HTMJ, Available at: .

Setianingsih, H., Putri, F.S.S., Desi, W.P.M. and Yatnasari, E., 2020. The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence. Indonesian Journal of Medical Sciences and Public Health, 1(1), pp.7–12. https://doi.org/10.11594/ijmp.01.01.02.

Kusumasari, F.C., 2023. Pengaruh Perbandingan Obat-Polimer terhadap Karakteristik Fisik Mikrokapsul Simvastatin. Jurnal Mandala Pharmacon Indonesia, 9(1), pp.111–118. https://doi.org/10.35311/jmpi.v9i1.316.

Nyoman Wiadnyana, N., Puspasari, R. and Ralph Thomas Mahulette, dan, 2008. Status Sumber Daya Dan Perikanan Teripang Di Indonesia: Pemanfaatan Dan Perdagangan.

Andriyono, S., Masithah, E.D. and Winarni, D., 2015. The Study of Sea Cucumber (Phyllophorus sp.) Gonads Histology: Thermal Shock to the Spawning Process lecture View project Mitochondrial DNA sequencing of Antarctic fish View project The Study of Sea Cucumber (Phyllophorus sp.) Gonads Histology: Thermal Shock to the Spawning Process. [online] Journal of Natural Sciences Research www.iiste.org ISSN, Available at: <https://www.researchgate.net/publication/317092474>.

KKP 2023 | Kementerian Kelautan dan Perikanan. [online] Available at: <https://kkp.go.id/djprl/bpsplpadang/page/319-teripang> [Accessed 8 June 2023].

Zhao, Y.C., Xue, C.H., Zhang, T.T. and Wang, Y.M., 2018. Saponins from Sea Cucumber and Their Biological Activities. Journal of agricultural and food chemistry, [online] 66(28), pp.7222–7237. https://doi.org/10.1021/ACS.JAFC.8B01770

Susila Ningsih, I., Chatri, M. and Advinda, L., 2023. Flavonoid Active Compounds Found In Plants Senyawa Aktif Flavonoid yang Terdapat Pada Tumbuhan.

Panjaitan, F.W.F., Kaseke, M.M., Tanudjaja, G.N., Skripsi, K., Kedokteran, F., Sam, U., Manado, R., Anatomi, B., Fakultas, H., Universitas, K. and Ratulangi, S., 2013. Gambaran Histologik Aorta Tikus Wistar Dengan Diet Lemak Babi Setelah Pemberian Ekstrak Daun Pepaya.

Fatmawati, Fony Marcelia and Yayah Badriyah, 2020. Pengaruh Ekstrak Daun Kelor (moringa oleifera).

Heriansyah, T., 2013. Pengaruh Berbagai Durasi Pemberian Diet Tinggi Lemak Terhadap Profil Lipid Tikus Putih (Rattus Novergicus Strain Wistar) Jantan.

Fitriarini, S. (Setya) and Rahayuningsih, H.M. (Hesti), 2014. Perbedaan Pengaruh Antara Ekstrak Dan Rebusan Daun Salam (Eugenia Polyantha) Dalam Pencegahan Penurunan Kadar Kolesterol Hdl Pada Tikus Sprague Dawley. Journal of Nutrition College, [online] 3(1), pp.184–191. Available at: <https://www.neliti.com/publications/96405/> [Accessed 16 November 2023].

Ekananda, N.A., 2015. [ARTIKEL REVIEW] Bay Leaf In Dyslipidemia Therapy. Dyslipidemia Therapy J Majority |, .

Jim, E.L., 2014. Metabolisme Lipoprotein. Jurnal Biomedik (JBM), 5(3). https://doi.org/10.35790/jbm.5.3.2013.4335.

Magfirah, Indah Kurnia Utami and Syafika Alaydrus, 2020. Effect of Seaweed Ethanol Extract on Cholesterol Levels and Obesity in White Rats. Jurnal Jamu Indonesia, 5(3), pp.98–105. https://doi.org/10.29244/jji.v5i3.175.