Perbandingan Efektivitas Platelet Rich Plasma VS Hypertonic Dextrose Prolotherapy terhadap Perbaikan Klinis Pasien Osteoartritis Genu

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Published: Nov 28, 2024
DOI: https://doi.org/10.30649/htmj.v22i1.639
Keywords:
osteoarthritis regenerative therapy comparison

Main Article Content

EKA POERWANTO
Departemen Kedokteran Fisik dan Rehabilitasi Medik, Rumah Sakit Pusat Angkatan Laut Dr Ramelan, Fakultas Kedokteran Universitas HangTuah
HENDRATA ERRY ANDISARI2
Departemen Ilmu Penyakit Dalam, Rumah Sakit Pusat Angkatan Laut Dr Ramelan, Fakultas Kedokteran Universitas HangTuah
Rr. MUTIARA DEVANIA SAMARA QALBA
Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Hang Tuah
RONALD PRATAMA ADIWINOTO
Departemen Ilmu Kesehatan Masyarakat, Fakultas Kedokteran Universitas HangTuah

Abstract

ABSTRACT


Background:


Knee osteoarthritis (OA) affects mainly older individuals, causing joint degeneration and decreased mobility. While current treatments include medications and surgery, regenerative therapies like Platelet Rich Plasma (PRP) and Hypertonic Dextrose Prolotherapy (HDP) offer promising alternatives. This study aims to compare the effectiveness of PRP and HDP injections in knee OA patients, providing insights into optimal treatment choices.


Methods:


This experimental analytical study involved two groups of participants. Group 1 (N=20) received PRP injections three times into both knees with four-week intervals. Group 2 (N=20) received HDP injections with 20% concentration into both knees with the same intervals. Numeric Rating Scale (NRS) and Western Ontario and McMaster University Arthritis Index (WOMAC) scores were assessed before and after injections to evaluate changes in pain, stiffness, and functional limitation.


Results:


Both PRP and HDP injections significantly reduced NRS scores, pain, stiffness, functional limitation, and total WOMAC scores. The reduction in pain, functional limitation, and total WOMAC scores was higher with HDP, while PRP was more effective in reducing stiffness. Mild pain during injection and knee swelling were reported by some participants, but no systemic complaints were noted, and all side effects resolved within a week.


Conclusion:


Both PRP and HDP injections are equally effective in reducing pain and stiffness and improving function in knee OA patients. These procedures offer promising, cost-effective, and easily administered therapies for knee OA, with HDP being a more cost-efficient option compared to PRP.


 


Keywords: Osteoarthritis, regenerative therapy, comparison

Article Details

How to Cite
POERWANTO, E., HENDRATA ERRY ANDISARI2, Rr. MUTIARA DEVANIA SAMARA QALBA, & RONALD PRATAMA ADIWINOTO. (2024). Perbandingan Efektivitas Platelet Rich Plasma VS Hypertonic Dextrose Prolotherapy terhadap Perbaikan Klinis Pasien Osteoartritis Genu. Hang Tuah Medical Journal, 22(1), 77–96. https://doi.org/10.30649/htmj.v22i1.639
Issue
Vol. 22 No. 1 (2024): Hang Tuah Medica Journal
Section
Articles

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