Comparison of Thrombocyte Nadir between Dengue Fever and Dengue Hemorrhagic Fever Patients

WISNU TRANAYA PUTRA; SRI MASYENI; KOMANG TRISNA SUMADEWI; SARASWATI LAKSMI DEWI

doi:10.30649/htmj.v23i2.963

Authors

WISNU TRANAYA PUTRA Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia
SRI MASYENI Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Bali
KOMANG TRISNA SUMADEWI Department of Anatomy, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Bali
SARASWATI LAKSMI DEWI Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Bali

DOI:

https://doi.org/10.30649/htmj.v23i2.963

Keywords:

dengue infection, thrombocyte, nadir, difference

Abstract

Background: Dengue infection remains a major public health problem and is frequently accompanied by thrombocytopenia. The lowest platelet level during illness (thrombocyte nadir) may reflect clinical severity and assist in early risk stratification. Objective: To compare the mean thrombocyte nadir between patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Methods: A cross-sectional study was conducted using medical record data of 150 hospitalized dengue patients at Sanjiwani Hospital (2022–2024). Dengue was confirmed by IgM anti-dengue testing or NS1 antigen detection. DHF was defined as a ≥20% increase in hematocrit at admission. Patients with a history of idiopathic thrombocytopenic purpura were excluded. Demographic and clinical data were summarized descriptively, and differences in thrombocyte nadir between DF and DHF were analyzed statistically. Results: Of 150 patients, 119 (79.3%) had DF and 31 (20.7%) had DHF. The thrombocyte nadir differed significantly between groups, with DHF demonstrating a lower nadir than DF (p = 0.001). Conclusion: Thrombocyte nadir is significantly lower in DHF compared with DF, supporting the usefulness of serial platelet monitoring to aid severity assessment and clinical surveillance in hospitalized dengue patients.

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