Hubungan Pemberian Terapi Oksigen Hiperbarik Terhadap Aktifitas Osteoblastik Dan Osteoklastik Pada Tikus Model Fraktur
DOI:
https://doi.org/10.30649/htmj.v19i2.267Kata Kunci:
terapi OHB, Fraktur, kalus, osteoblas, osteoklas, Tikus wistarAbstrak
Latar Belakang : Fraktur adalah suatu keadaan terputusnya tulang akibat tekanan signifikan yang dapat berupapembengkokan, puntiran, atau tarikan akibat trauma, kecelakaan kerja, kecelakaan lalu lintas, serta proses degenerasi dan patologis. Fraktur dapat mengakibatkan hilangnya produktivitas dan kecacatan individu. Salah satu terapi adjuvant untukmempercepat proses penyembuhan tulang pada pasien fraktur adalah Terapi Oksigen Hiperbarik (OHB).
Tujuan:Penelitian ini bertujuan untuk mengetahui pengaruh terapi oksigen hiperbarik terhadap jumlah osteoblas dan osteoklas yang terbentuk pada tikus model fraktur femur diafisis.
Metode :Penelitian ini merupakan penelitian eksperimen dengan menggunakan post test only control group design. Objekdalam penelitian ini adalah model fraktur tikus dengan terapi OHB sebagai variabel bebas dan model fraktur tanpa terapiOHB sebagai variabel kontrol.
Hasil: Hasil penelitian ini menunjukkan hasil positif tentang pengaruh terapi Oksigen Hiperbarik terhadap pembentukansel osteoblastik dan osteoklastik.
Kesimpulan: Adanya perbedaan signifikan dari jumlah osteoblas dan osteoklas pada tikus model fraktur yang diterapi OHB dibandingkan dengan yang tidak diterapi OHB.
Kata kunci: Terapi OHB, Fraktur, Kalus, Osteoblas, Osteoklas, Tikus Wistar
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