Pengaruh Pemberian Ekstrak Daun Mahkota Dewa(Phaleria Macrocarpa) pada Gambaran Histopatologi Paru Tikus Putih (Rattus Norvegicus) Galur Wistar yang Dipapar Asap Rokok

Abstract

ABSTRACT

Background Smoking and getting exposed to cigarette smoke in a long period of time can cause inflammatory response on respiratory tract. Mahkota dewa leaf contains beneficial biological component, such as flavonoid, alkaloid, and saponin that have anti-inflammatory, anti-cancer, and many others.

Aim : to determine the effect of administration of mahkota dewa leaf (Phaleria macrocarpa) extract of inflamatory cells on lung histopathology in white male Wistar rats (Rattus norvegicus) exposed to cigarette smoke.

Methods :  experimental research using Post-Test Only Control Group Design. The subject in this research were 30 male Wistar Rats (Rattus norvegicus) which were divided into 4 groups, a group without given any treatment (K-), a group where they only getting exposed to cigarette smoke (K+), a group where they exposed to cigarette smoke and given mahkota dewa leaf extract at 1500 mg/kgBW/day dose (K1), and the group exposed to cigarette smoke and a mahkota dewa leaf extract at a 2500 mg/kgBW/day dose (K2). , then the rats sacrificed to be made lung histological preparats to count the number of inflamatory cells

Result            :  There was a significant difference on lung histopathology between K- and K+, P1, and P2.  There was no significant difference infiltration cells on lung histopathology between K+, K1 and K2.

Conclusion : Exposure to 5 cigarette smoke in 21 days caused lung histopathology changes. However, there was no effect of the administration of mahkota dewa leaves extract at 1500 mg/kgBW/day and 2500 mg/kgBW/day on lung histopathology of white male Wistar rats exposed to 5 cigarette smoke in 21 days